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Here, we report the x-ray structure (2.4 Å) of the IL-6R ectodomains. The N-terminal strand of the Ig-like domain (D 1) is disulfide-bonded to domain D 2, and domains D 2 and D 3, the cytokine-binding domain, are structurally similar to known cytokine-binding domains. The head-to-tail packing of two closely associated IL-6R molecules observed.
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Communications Biology - A vgrG database was established, which revealed six widely distributed domain families with similar genetic configurations.. VgrG (PDB 6sk0) contains a DUF2345 domain.
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α/β-Hydrolase domain 6 (ABHD6) is an enzyme that has been recently reported to regulate 2-arachidonylglycerol (2-AG) hydrolysis [ 6 ]. 2-AG serves as an important lipid precursor for the eicosanoid signalling pathway and also functions as an endogenous signalling lipid for the activation of cannabinoid receptor 1 and 2 (CB1 and CB2.
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The .bio domain extension is a generic top-level domain (gTLD) that was approved by ICANN (Internet Corporation for Assigned Names and Numbers) in 2014 and is managed by STARTING DOT, an internet domain registry. The .bio extension has a double significance: it pertains to both the French term "biologique" (English: organic), making it.
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Objective. α/β-Hydrolase domain-6 (ABHD6) is a newly identified monoacylglycerol (MAG) lipase. We recently reported that it negatively regulates glucose stimulated insulin secretion (GSIS) in the β cells by hydrolyzing lipolysis-derived MAG that acts as a metabolic coupling factor and signaling molecule via exocytotic regulator Munc13-1.
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The transmembrane and cytoplasmic domains of the IL-6R are not required for IL-6 signal transduction ().Biologically active forms of the extracellular region of the IL-6R or "soluble IL-6R" (sIL-6R; ref. 19) are found naturally in low concentrations in human urine and serum of healthy individuals ().Increased sIL-6R levels have been reported in a number of clinical conditions (e.g., HIV.
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Organisms can be classified into one of three domains based on differences in the sequences of nucleotides in the cell's ribosomal RNAs (rRNA), the cell's membrane lipid structure, and its sensitivity to antibiotics. The three domains are the Archaea, the Bacteria, and the Eukarya. Prokaryotic organisms belong either to the domain Archaea or.
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About .bio domains. Select a category below to get information about price, terms and restrictions, registration details, privacy protection, and more for . bio domains. Country code top-level domains (ccTLDs) are generally used or reserved for a country, sovereign state, or dependent territory.
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Human alpha/beta hydrolase domain 6 (hABHD6) is an enzyme that hydrolyzes 2-arachidonoylglycerol (2-AG), a potent agonist at both cannabinoid CB1 and CB2 receptors. In vivo modulation of ABHD6.
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Glucose must be metabolized by pancreatic β cells to promote glucose-stimulated insulin secretion (GSIS). Zhao et al. found that saturated long-chain monoacylglycerol acts as metabolic coupling factor for GSIS, activating the exocytotic effector Munc13-1, and that the monoacylglycerol signal is controlled by α/β-Hydrolase Domain 6 (ABHD6).
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Renewal length: 1-10 years. If you have auto-renew enabled, we'll attempt to charge the associated payment method and renew your .BIO domain on its expiration date. If auto-renew fails or isn't enabled at all, we'll park your .BIO domain. A parked domain will display a temporary web page when the domain name is entered in a web browser.
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Human alpha/beta hydrolase domain 6 (hABHD6) is an enzyme that hydrolyzes 2-arachidonoylglycerol (2-AG), a potent agonist at both cannabinoid CB1 and CB2 receptors.. (5 μL of 550 mM) for 1 hr, respectively. The samples were desalted with a Bio-Spin 6 Column in 50 mM ammonium bicarbonate buffer containing 0.05% w/v octyl-β-glucoside, pH 8.0.