Figure 1 from PIM 1 kinase as a target for cancer therapy Semantic Scholar
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On the contrary, Pim-1 overexpression can down-regulate E-cadherin, up-regulate vimentin, and increase stem-like characteristics, ultimately. 24,25 In light of the vital roles of Pim1 in tumor progression, it is our believe that Pim-1 maybe a promising candidate biomarker for cancer with great clinical significance.
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PIM-1 nanoparticles were synthesized using an anti-solvent precipitation method,res as reported previously [8]. To fabricate nanoparticulate films, a volume of 5 ฮผL (4 mg mL โ1) of PIM-1 solution (corresponding to 20 ฮผg PIM-1) was dropped onto the graphene foam electrode and dried at room temperature. Dense films were obtained by deposition.
Molecular structures of PIM1 and PIM7. Copyright permission obtained... Download Scientific
In this study, we present the fabrication of fibers with tunable morphology and porosity from an intrinsically microporous polymer, PIM-1, using a simple one-step electrospinning technique. The method involves the dissolution of PIM-1 in a good solvent tetrahydrofuran (THF) and cosolvents composed of THF and a nonsolvent, either dimethylformamide (DMF) or toluene, for electrospinning without.
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PIM1. Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene. [5] [6] [7] Pim-1 is a proto-oncogene which encodes for the serine/threonine kinase of the same name. The pim-1 oncogene was first described in relation to murine T-cell lymphomas, as it was the locus most frequently activated by.
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Carbon molecular sieve membranes (CMSMs) commonly lose permeability over time due to the collapse of micropores. This decline in permeability, due to the densification of the membrane, is known as physical aging. CMSMs derived from polymers of intrinsic microporosity (PIM-1) are highly affected by physical aging, with declines in permeability greater than 60% over time. It is hypothesized that.
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ZIF-8 gel; Polymer of intrinsic microporosity (PIM-1); Hโ/CHโ separation. Developing high-performance H2/CH4 separation membranes is of great potential for H2 production in the petroleum industry. Incorporating nanofillers into a polymer matrix to form mixed matrix membranes (MMMs) can elevate selectivity and permeability, but poor polymer.
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Previously, we reported that PRL directly stimulated rapid expression of the protooncogene, pim-1, at the mRNA and protein levels in lactogen-dependent Nb2-11 cells. In the present study, experiments were conducted to evaluate signaling mechanisms by which PRL regulates transcription of pim-1. Toward this end, a 1,268-bp segment upstream of the.
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PIM-1 incorporated with beta-cyclodextrin (ฮฒ-CD) were prepared by Chung's group [100], as shown in Fig. 7 b. The unique 3-dimensional (3D) hollow bowl structure of ฮฒ-CD endowed the obtained MMMs with 162% higher CO 2 permeability with slight sacrifice of 1% for CO 2 /N 2 selectivity and 2% for CO 2 /CH 4 selectivity, and physical aging.