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Background Guidelines recommend that treatment with a long-acting β2 agonist (LABA), a long-acting muscarinic antagonist (LAMA), and inhaled corticosteroids (ICS), i.e. triple therapy, is reserved for a select group of symptomatic patients with chronic obstructive pulmonary disease (COPD) who continue to exacerbate despite treatment with dual therapy (LABA/LAMA). A number of single-inhaler.
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Rationale: There is uncertainty on the optimal first-line therapy for symptomatic chronic obstructive pulmonary disease (COPD). Long-acting β 2-receptor agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) have long been mainstays of treatment, though it is still not clear if dual therapy with LABA/LAMA is superior to monotherapy for symptomatic COPD.
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The long-acting agents include two classes of drugs: the long-acting β 2 -agonists (LABAs), eg, salmeterol and formoterol; the anticholinergics, eg, tiotropium. Formoterol and salmeterol are both long-acting bronchodilators that are effective in the treatment of asthma ( Lötvall 2001 ). After single doses, clear effects are maintained for 12.
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Results: A total of 22 studies involving 16,486 participants were included in this study. The results showed that in terms of primary outcome (change from baseline in trough FEV 1), the efficacy of vilanterol/umeclidinium was the highest, while the efficacy of formoterol/aclidinium was the lowest, with a maximum effect value (E max) of 0.185 L [95% confidence interval (CI): 0.173-0.197 L.
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Two study sub-cohorts (LABA/LAMA and LABA/ICS) were built based on 1:1 matching through the greedy-matching algorithm (without replacement) and on the propensity score. 22 A logistic regression model was used to construct a propensity score that predicts the patient's probability of initiating LABA/LAMA or LABA/ICS treatment. The following.
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Laba laba adalah sejenis hewan teluk (arthropoda) dengan dua anggota badan, empat pasang kaki, tidak bersayap dan tidak memiliki mulut pengunyah. Racun yang disuntikkan laba-laba melalui taringnya biasanya dicerna dan merusak bagian dalam tubuh mangsa secara bersamaan.
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LABA/LAMA combination therapy showed no difference in treatment-emergent adverse effects (risk ratio, 0.99; P=0.34) when compared with either LAMA or LABA monotherapy. Conclusions: Based on the reviewed evidence, in patients with symptomatic COPD who complain of dyspnea and/or exercise intolerance, dual LABA/LAMA therapy is superior to either LABA
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Long-acting β adrenoceptor agonists ( LABAs, more specifically, long-acting β 2 adrenergic receptor agonists) are usually prescribed for moderate-to-severe persistent asthma patients or patients with chronic obstructive pulmonary disease (COPD).
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LAMA-LABA COPD only Anoro® Ellipta umeclidinium and vilanterol 55/22, 62.5/25 mcg Bevespi Aerosphere®Respimat glycopyrrolate and formoterol 9/4.8 mcg Stiolto® Respimat® olodaterol and tiotropium bromide 2.5/2.5 mcg C Lung HelpLine: 1-800-LUNGUSA A | Lung.org Dulera® mometasone furoate and formoterol fumarate dihydrate 50/5, 100/5, 200/5 mcg A
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A systematic literature search of randomized controlled trials published in English up to September 2017 of LABA/LAMA FDCs vs LABA or LAMA or LABA/inhaled corticosteroid (ICS) FDCs in COPD patients was performed using PubMed, Embase, Scopus, and Google Scholar. Outcomes including forced expiratory volume in 1 second (FEV 1 ), Transition Dyspnea.
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Objectives. This study aimed to quantitatively compare the efficacy and safety of long-acting β 2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) and LABA/inhaled corticosteroid (ICS) fixed-dose combinations (FDCs) in preventing moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations.. Methods. A literature search was performed using public databases.
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What are LABAs? LABAs are also known as bronchodilators. Bronchodilators come in the form of short-acting or long-acting. 1 Short-acting beta-agonists (SABAs) are used as-needed as a " rescue inhaler " or to prevent exercise-induced asthma. LABAs, on the other hand, are taken every day. A LABA is not to be used as a rescue inhaler. 1
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Background Recently, the addition of inhaled corticosteroid (ICS) to long-acting muscarinic antagonist (LAMA) and long-acting beta-agonist (LABA) combination therapy has been recommended for patients with COPD who have severe symptoms and a history of exacerbations because it reduces the exacerbations. In addition, a reducing effect on mortality has been shown by this treatment. However, the.
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Long acting beta agonist can be divided into once-daily and twice-daily LABA. Once-daily LABA are currently called ultra-LABA. Ultra-LABA are ultra-long acting and are dosed once a day such as indacaterol (IND), olodaterol (OLO), and vilanterol (VIL); they provides both the quick bronchodilation effect similar to short-acting beta agonists, and a 24-h bronchodilation effect permitting the once.
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Chronic obstructive pulmonary disease (COPD) poses a paramount clinical burden worldwide. It is the third and the eighth major cause of mortality globally and in Taiwan, respectively [1, 2].Long-acting bronchodilators, including long-acting β 2 agonists (LABA) and long-acting muscarinic antagonists (LAMA), are the central maintenance treatment in reducing COPD-related symptoms and.
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Objectives: This study aimed to quantitatively compare the efficacy and safety of long-acting β 2-agonist (LABA)/long-acting muscarinic antagonist (LAMA) and LABA/inhaled corticosteroid (ICS) fixed-dose combinations (FDCs) in preventing moderate or severe chronic obstructive pulmonary disease (COPD) exacerbations. Methods: A literature search was performed using public databases.
